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法國科學家關於轉基因玉米毒副作用的最新論文 [原創 2010-04-02 11:59:39]
剛剛看到這裡全文轉載的法國科學家4個月前（2009年12月）最新發表的學術研究成果，揭示了市面上的三個主要轉基因玉米品種在小白鼠餵食試驗中呈現出毒副作用。據介紹，論文是發表在相當可靠的純學術刊物上，「該國際生物學刊為純學術刊物，編委會由中歐美澳等國的生物學、基因學和醫學等相關學科的專業學者組成；諾貝爾科學獎獲得者、分子遺傳學轉家馬里奧·卡佩奇等三位美國國家科學院院士（包括中國科學家陳竺）入盟為編委成員。」（見上述全文轉載網址）這篇論文再次引起廣泛關注，美國衛生部也有轉發。我剛剛在 google.com 搜索 "A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health" 獲得約 11,000 條結果（註：搜索時帶雙引號，以精確匹配整個標題）
這裡將其摘要轉貼並翻譯如下。（譯得不對，請大家不吝賜教）
論文標題：A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health.
發表刊物：Int J Biol Sci 2009; 5:706-726, Ivyspring International Publisher.
發表時間：Received 2009-7-23 /Accepted 2009-11-17 /Published 2009-12-10 .
鏈接網址：http://www.biolsci.org/v05p0706.htm / http://www.biolsci.org/v05p0706.pdf
美國衛生部發表網址：http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793308/
Abstract: We present for the first time a comparative analysis of blood and organ system data from trials with rats fed three main commercialized genetically modified (GM) maize (NK 603, MON 810, MON 863), which are present in food and feed in the world. NK 603 has been modified to be tolerant to the broad spectrum herbicide Roundup and thus contains residues of this formulation. MON 810 and MON 863 are engineered to synthesize two different Bt toxins used as insecticides.
摘要：我們首先提出由老鼠餵食試驗得到的血液和器官系統比較分析，所餵食的是三種主要的商業化轉基因（GM）玉米（NK 603, MON 810, MON 863），它們目前在全世界作為食品和飼料供應。NK 603被改造為可耐受廣譜除草劑Roundup因而包含這一配方殘餘，MON 810 與 MON 863被改造合成了兩種不同的用於殺蟲的Bt毒素。
Approximately 60 different biochemical parameters were classified per organ and measured in serum and urine after 5 and 14 weeks of feeding. GM maize-fed rats were compared first to their respective isogenic or parental non-GM equivalent control groups. This was followed by comparison to six reference groups, which had consumed various other non-GM maize varieties. We applied nonparametric methods, including multiple pairwise comparisons with a False Discovery Rate approach. Principal Component Analysis allowed the investigation of scattering of different factors (sex, weeks of feeding, diet, dose and group).
在餵食5周和14周之後，分別通過器官和血清和尿樣測試大約60項不同的生物化學指標。GM餵食的老鼠，首先與它們各自的同基因或同父母非轉基因等效對照組比較，隨後比較六個參考組，它們用各種其它非轉基因玉米品種餵養。我們採用非參數方法，包括帶有False Discovery Rate（性別，餵食周，飲食，劑量組）的多重成對比較。
Our analysis clearly reveals for the 3 GMOs new side effects linked with GM maize consumption, which were sex- and often dose-dependent. Effects were mostly associated with the kidney and liver, the dietary detoxifying organs, although different between the 3 GMOs. Other effects were also noticed in the heart, adrenal glands, spleen and haematopoietic system.
對於這3個轉基因物種，我們的分析清楚地揭示了與轉基因玉米消耗關聯的新副作用，有性別和經常是劑量依賴性。雖然在三個轉基因品種之間有區別，但產生的影響大多關係到腎臟和肝臟，飲食排毒器官。其它方面，還提示了在心臟、腎上腺、脾、造血系統方面的影響。
We conclude that these data highlight signs of hepatorenal toxicity, possibly due to the new pesticides specific to each GM corn. In addition, unintended direct or indirect metabolic consequences of the genetic modification cannot be excluded.
我們的結論是，這些數據突出顯示了肝腎毒性的徵象，可能歸因於每個轉基因玉米中的新增的特定殺蟲劑。此外，也不能排除意外直接或間接代謝的遺傳修飾的後果。
博主評論：還是那句老話，我們雖然不懂這個專業，但通過地觀察不同來源的信息，來源的可靠程度，信息作者的背景，足以作出可靠的判斷：對於現有的轉基因物種是否有害，至少不是像國內專家信誓旦旦說教的一面倒的結論。至少已經存在毒副作用的科學研究報告。在這種情況之下，能任其泛濫嗎？原來我每周都要從超市買一些甜玉米之類，最近我不在買了，因為我跟本不知道那是否轉基因品種。 |
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發表於 2010-7-24 08:19
我以為合格的論據應該包括這樣幾點