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美國衛生部更新記錄肯定肖傳國科研繼續進行。 (22 查看)
日期: February 28, 2011 09:16AM
美國衛生部更新記錄肯定肖傳國科研繼續進行。
直言了，2011-02-28。
再有幾天，肖傳國即將獲得自由。肖某之案是個冤案，是方舟子、方玄昌和彭劍在一些媒體協助下、用偽造證據和偽報案情而煽動社會而造成的迫害正直學者的冤案。面臨肖某即將獲得自由，那幫人試圖再次煽動社會、否定肖某科研。此時此刻，自稱「放棄美國國籍」而實際上還是美國公民的北大官員饒毅，也入盟加火，先是為方舟子造加行為辯護而偽造了所謂學刊「編委會」結論的信件，然後，又支持方舟子等三人的誣告陷害活動、試圖用他偽造的所謂項目審核「標準」來否定肖傳國的手術科研。
就在他們在中國媒體上蠢蠢欲動的時候，在美國、經過記錄審核、美國衛生部於2011-02-24更新網站數據，再次充分肯定肖傳國的手術科研，繼續原定的資助肖某項目的計劃。附后是相關網頁的內容摘錄，請您分享參考。
在此之前的早些時候，方舟子等人投訴美國官方機構，用偽造證據指控肖傳國的手術科研是「造假」。該更新說明，美國官方全部駁回了方某他們的造謠誹謗。根據網友說，在駁回信件中，美國相關機構明確要求方某們看看相關法規規範、搞懂相關條款再提指控。按照慣例，那種駁回實際上就是批評方某等人的指控是「BAD-FAITH」（即無信用可言的和涉嫌誣告陷害的誹謗性指控），只不過講講客氣而沒直接用「BAD-FAITH」去批評方某等人的惡行、而是用「溫和」卻是「更損」的詞語批評他們，即請他們把起碼常識搞懂了再說如何指控的事。
美國衛生部的更新記錄提到了肖傳國手術科研的逐步走向成功的過程，說明了當前科研階段的攻研主題，並保持了原定的項目成功與否的審核標準規範。看看那些內容、再做個對比，可以清楚看到，方某三人和饒毅他們對肖傳國搞的指控，全都是幾個外行不懂裝懂、用偽造證據搞造謠誹謗的誣告陷害活動。
需要說明的是，在美國，類似衛生部直接資助的科研項目的決策以及跟蹤監督進展記錄和更新記錄，都是經過同行評議的，整個過程和內容也是向所有公民公開的。就是說，且不說同行評議和公民公開知情都肯定了肖某科研，而且，就是有人想「找碴」或「雞蛋裡挑骨頭」來批評甚至試圖否定該項目，也是隨時隨地可行的。然而，那樣的事情在美國是沒發生的，而方某他們的那種企圖被全部駁回，這足以說明肖某科研不但沒有任何「造假」事情，而且是經過考驗檢驗而再次獲得美國衛生部及同行評議的充分肯定。
我想，可以說，這是為肖傳國即將獲得自由的一個最佳歡迎和最佳祝賀。
附件：美國衛生部更新記錄，再次表明繼續資助肖傳國的手術科研。
（註：這是摘錄。對全部詳情感興趣，可用地址連接去閱讀原文全文）。
Nerve Rerouting Treatment for Neurogenic Bladder in Spina Bifida
This study is not yet open for participant recruitment.
Verified by William Beaumont Hospitals, June 2010
First Received: March 23, 2010 Last Updated: June 4, 2010
ClinicalTrials.gov processed this record on February 24, 2011
[www.clinicaltrials.gov]
Sponsor: William Beaumont Hospitals.
Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Information provided by: William Beaumont Hospitals.
ClinicalTrials.gov Identifier: NCT01096459 .
Detailed Description:
Spina Bifida (a congenital defect of the spinal cord), causes nerve damage and a loss of sensation and muscle function below the waist resulting in bowel and bladder dysfunction. Patients cannot urinate or are constantly wet, and this continues throughout life causing major quality of life and health problems. Clean intermittent catheterization (draining urine from the bladder with a tube) is usually needed to empty the bladder properly. Medications are routinely required to alleviate high urinary tract pressures that can cause irreversible kidney damage, where dialysis or kidney transplant is the only way to sustain life.
Dr. Xiao, a Chinese urologist, developed a novel procedure to connect a functioning, healthy lumbar spinal nerve to the sacral nerve that controls the bladder. Hundreds of these procedures have been done in China with good results. The end result is the creation of a new reflex where the bladder can be emptied by scratching or stimulating the skin (over the hip or thigh) supplied by that spinal nerve root. He has reported that in 92 SCI patients, 88% regained bladder control within one year after the nerve rerouting surgery and in 110 children with spina bifida, reported success was 87% at one year. However, in China rigorous follow up is challenging, therefore much is still unknown about how the nerves regenerate post surgery, complications and results occurring in the first year in particular, and the potential role that central nervous system remodeling may play in achieving successful outcomes. Beaumont urologists, in collaboration with Dr. Xiao, were the first in the US to perform this surgery on children with spina bifida. Our preliminary data are very promising, and in 9 subjects at 12 months post procedure, 7/9 subjects could void either voluntarily or by stimulating the new reflex mechanism.
This current project aims to expand upon our pilot experience to conduct a larger and more rigorous study to establish the safety and effectiveness of the proposed somatic-autonomic reflex pathway procedure in gaining bladder and bowel control in patients with spina bifida. We will also collaborate with and train investigators at another site(s) to determine the training needed to achieve similar safety and effectiveness outcomes, and evaluate possible methods to stimulate the new reflex to improve bladder emptying. Achieving the aims outlined in this multicenter proposal will help firmly establish the procedure as safe and effective, and revolutionize the treatment of bladder and bowel dysfunction in patients with spina bifida in the US.
Eligibility
Criteria
Inclusion Criteria:
- Male and female patients age 5 and older with spinal dysraphism (ie. myelomeningocele , lipomyelomeningocele, myelocele, meningocele, occulta) with voiding dysfunction on a CIC program for bladder management for at least one year prior to screening.
-Atonic or hyperreflexic bladder documented by urodynamic testing during screening. .
Documented history of no more than one tethered cord surgery/release in the past; must be > 2 years post tethered cord surgery/release.
- Stable neurogenic bladder dysfunction of at least 1 year or more.
- Normal renal function (cr<1.5 mg/dl or GFR >75).
- Ambulate independently with or without ankle-foot orthotics (AFOs).
- Catheterized volume must be at least 50% of total bladder capacity.
Exclusion Criteria:
01. History of bladder cancer, augmentation, or radiation;
02. Anatomic outlet obstruction or urethral strictures;
03. History of untreated vesico-ureteric reflux grade 4 or higher documented on screening video UDT;
04. Hydronephrosis grade 3 or higher;
05. Presence of an ileal conduit or supra-pubic catheter drainage;
06. Subjects with an artificial bladder sphincter;
07. Subjects who have had a sling procedure;
08. Subjects who have had the mitrofanoff procedure;
09. Bladder botox injections within last 12 months;
10. Spina Bifida subjects who underwent intrauterine closure of their myelomeningocele;
11. Unable to ambulate independently with or without AFOs;
12. Subject is pregnant;
13. Contraindications to general anesthesia or surgery;
14. Inability to complete follow up visits for 2 years;
15. Inability to complete (or have parent complete) self administered questionnaires;
16. Subject possesses any other characteristics that, per investigator's judgment, deems them unsuitable (eg increases risk, impairs data collection, etc) for the procedure/study.
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