Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity:

http://www.ncbi.nlm.nih.gov/entr ... splay&DB=pubmed

Copeland RL Jr, Leggett YA, Kanaan YM, Taylor RE, Tizabi Y.

Department of Pharmacology and Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA.

Parkinson's disease is associated with degeneration of dopaminergic cell bodies in the substantia nigra. It has been suggested that salsolinol, an endogenous metabolite of dopamine, may be involved in this process. An inverse relationship between Parkinson's disease and smoking (nicotine intake) has been observed in epidemiological studies. Moreover, neuroprotective effects of nicotine in various experimental models have been observed. In this study we sought to determine whether salsolinol-induced cytotoxicity in SH-SY5Y human neuroblastoma cells, a cloned cell line which expresses dopaminergic activity, could also be prevented by nicotine pretreatment, and if so, which nicotinic receptors may mediate the actions of nicotine. Exposure of SH-SY5Y cells to 0.8 mM salsolinol for 24 hours resulted in approximately 80% cell death as determined by 3,[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Pretreatment of cells with 0.1 mM nicotine resulted in inhibition of salsolinol-induced cytotoxicity. The effects of nicotine were blocked by mecamylamine, a non-selective nicotinic antagonist as well as conotoxins with selective antagonism against alpha3-containing nicotinic receptor subunits. The effects of nicotine were not affected by dihydro-beta-erythroidine or methyllycaconitine, selective antagonists against alpha4-beta2 or alpha7 nicotinic receptors, respectively. It is suggested that selective nicotinic agonists may be of therapeutic potential in at least a subpopulation of Parkinsonian patients.

所以對任何事物都不要絕對化.

全文題應是Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's disease.
因受文題字數定為80字而刪改, 去掉了 implications for Parkinson's disease. 請諒解.

[ 本帖最後由 新鮮人 於 2006-12-30 12:34 編輯 ]

The Howard University College of Medicine first opened its doors as a medical department in 1868, just three years after the close of the Civil War. At that time, newly freed black people were migrating to the nation's capital in large numbers. The founders of the College recognized that the nearly overwhelming health care needs of this population and of other blacks throughout this country would be met best by training students to become highly competent, compassionate physicians who would deliver care in communities having a shortage of health personnel.  

That realization was translated into the mission of the Howard University College of Medicine, and the continuing fulfillment of that mission is evidenced by the illustrious record of service provided by the College's alumni and faculty.  

Today, while the College offers excellent research and research training opportunities, the major emphasis remains on preparing students to deliver high quality health care in medically underserved communities.
HOWARD UNIVERSITY
COLLEGE OF MEDICINE
520 W Street, N.W.
Washington, DC 20059
(202) 806-6270 Voice
(202) 806-7934 FAX

香煙為毒害人類身體健康的重要罪魁禍首,  轉貼本文祗是想告訴大家即使香煙也不是絕對無用於人類.  要具體分析. 這就是兩分法.
對中醫也同樣需要兩分法,  恐怕更不能一棍子打死.

[ 本帖最後由 新鮮人 於 2006-12-30 13:01 編輯 ]

世界上有那一個國家明文禁煙了嗎?  恐怕沒有. 祗有禁止在公共場所吸煙. 在非公共場合吸煙世界各國都是自由的,  為什麼一定要國家來廢除中醫呢?  就不能保留一些病人的自由選擇權?

什麼是廢除中醫? 什麼是告別中醫?  就不能讓它作為補充及替代醫學存在下去?  一定要趕盡殺絕?

煙和酒一樣,  都是有害於身體健康的不良物品,  但都要一分為二的對待,  要具體事物具體分析, 不能絕對化.  尤其是當醫生的更應知道.

又是 It is suggested that selective nicotinic agonists may be of therapeutic potential in at least a subpopulation of Parkinsonian patients.
這不是新鮮人提出的新鮮事,   不過有人說這"當不了真的. "  為什麼國外那麼多的人研究.   而且已被世界所公認?

[ 本帖最後由 新鮮人 於 2007-1-10 10:56 編輯 ]