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幹細胞和人體組的自我修復 ---7。成體幹細胞具有的分化能力

作者：HappyUSANA 於 2010-7-31 12:05 發表於最熱鬧的華人社交網路--貝殼村

通用分類:健康生活|已有30評論

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有網友反映寫的太專業、不通俗。因為我喜歡刨根問底，所以收集了專業的信息。等我完成後，再簡化、通俗化。由繁到簡應該容易。

7。成體幹細胞具有的分化能力
幹細胞研究領域著名的科學家之一喬治城大學醫學院Georgetown University Medical School Washington, D.C.教授David A. Prentice博士總結了一部分文獻，這些文獻說明成體幹細胞具有分化成幾乎所有組織和細胞的功能，因此稱之為亞全能幹細胞。
Evidence that Some Adult Stem Cells show Pluripotent Capacity
科學研究表明，一些成體幹細胞顯示出多能性的能力，例如
幹細胞能形成軟骨和骨 Stem cells can form cartilage and bone -Science (The world's leading journal of original scientific research) 284, 143-147; 2 Apr 1999
源自骨髓的幹細胞可能形成神經組織Bone marrow-derived stem cells appear able to form neuronal tissues，Science 290, 1775-1779; 1 Dec 2000
骨髓幹細胞能形成肝臟、皮膚和消化道細胞Bone marrow stem cells can form liver, skin, and digestive tract cells-New England Journal of Medicine 346, 738-746; 7 March 2002
骨髓幹細胞也可以參與皮膚癒合，促進傷口癒合修復Bone marrow stem cells can also participate in cutaneous healing, contributing to repair of wound healing -Journal Of Cellular Physiology 196, 245–250; 2003
幹細胞參與人腦新神經元的產生Stem cells participate in the generation of new neurons within the human brain -Proceedings of the National Academy of Sciences USA 100, 1364-1369; 4 Feb 2003
骨髓幹細胞也被證實有助於增加浦肯野細胞（Purkinje cells）Bone marrow stem cells have also been shown to contributeto Purkinje cells (Purkinje cells are brain cells that science had believed are not generated after birth科學界不久前還認為浦肯野細胞是出生后大腦中不能再生成的細胞) Proceedings of the National Academy of Sciences USA 100, 2088-2093; 18 Feb 2003
遊動性幹細胞也被用於心臟組織的重建Mobilized stem cells have also been used in renewal of cardiac tissue (Mobilized stem cells are those that have released into the bloodstream)-Journal of Clinical Investigation 107, 1395-1402; June 2001
骨髓幹細胞也表現出參與重建視網膜組織的能力Bone marrow stem cells have also shown the ability to participate in renewal of retinal tissues -Nature Medicine 8, 1004-1010; Sept 2002
人體骨髓幹細胞已被證明可以形成軟骨細胞 Human marrow stem cells have been shown to form cartilage cells -Proceedings of the National Academy of Sciences USA 99, 4397-4402; 2 Apr 2002
骨髓幹細胞也被證明能夠更新肌肉組織Bone marrow derived stem cells have also been shown capable of renewing muscle tissue -Science 279, 1528-1530; Mar 6, 1998
骨髓幹細胞能夠參與腎臟組織的恢復Bone marrow stem cells can participate in restoring kidney tissue -Journal of the American Society of Nephrology 14, S48-S54; 2003
骨髓幹細胞復育的肝細胞也能在人體發生Repopulation of liver cells from bone marrow stem cells could take place in humans -Nature 406, 257; 20 July 2000
骨髓幹細胞也表現出促使胰腺重建的能力 Bone marrow derived stem cells have also demonstrated the ability to induce renewal of the pancreas-Bone Marrow Transplant 215-222; Aug 2002
骨髓幹細胞可以更新心肌組織和改善人類心臟功能 Bone marrow derived stem cells can renew cardiac tissue and improve cardiac performance in humans -Nature Medicine 7, 430-436; April 2001 and many more
研究表明，骨髓幹細胞可以更新肺組織，減輕炎症 Studies indicate evidence that bone marrow stem cells can renew lung tissue-Development 128, 5181-5188; December 2001； Stem cells can home to lung tissue, then participate in renewal of lung tissue and reduction of inflammation-Proceedings of the National Academy of Sciences USA 100: 8407-8411; 8 July 2003
骨髓基質幹細胞已被證明有助於人類患者胃腸道組織重建Bone marrow derived stem cells have been shown to contribute to renewal of gastrointestinal tissue in human patients-Archives of Dermatology 137, 1071-1072; Aug 2001
骨髓幹細胞能形成所有3個胚層，並再生受損的心臟。Bone Marrow Stem Cells can form all 3 germ layers, and regenerate damaged heart.Yoon Y-s et al., 「Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction」, Journal of Clinical Investigation 115, 326-338, February 2005
人骨髓成體幹細胞多能性的潛力 Human Bone Marrow Adult Stem Cells with pluripotent potential， D』Ippolito G et al., 「Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential」, J. Cell Science117, 2971-2981, 15 July 2004 (published online 1 June 2004)
##########外周血造血幹細胞表達Oct - 4基因，能夠形成細胞所有的3個主要胚層，形成包括內皮細胞，神經細胞，肝細胞等。Peripheral blood stem cells express Oct-4 gene and can form cells from all 3 primary germ layers, including endothelial cells, neuronal cells, and liver cells. Zhao Y et al.; 「A human peripheral blood monocyte-derived subset acts as pluripotent stem cells」; Proceedings of the National Academy of Sciences USA 100, 2426-2431; 4 March 2003
形成人腦新的神經細胞Adult stem cells from bone marrow can form new neurons in the human brain. Mezey E et al.; 「Transplanted bone marrow generates new neurons in human brains」; Proceedings of the National Academy of Sciences USA 100, 1364-1369; 4 Feb 2003
形成所有組織Adult stem cells from bone marrow can form all body tissues，Jiang Y et al.; 「Pluripotency of mesenchymal stem cells derived from adult marrow」; Nature 418, 41-49; 4 July 2002
形成功能性骨髓，血細胞，肝細胞，肺細胞，小腸？？？皮膚細胞，心臟細胞，骨骼肌肉細胞 A single adult mouse bone marrow stem cell can form functional marrow, blood cells, liver,lung, gastrointestinal tract, skin, heart and skeletal muscle.Krause DS et al.; 「Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell」; Cell 105, 369-377; 4 May 2001

希望以上文獻能回答網友關於成體幹細胞能否分化為身體所需要的細胞／組織和器官的問題。當然上面的文獻只是很少一部分，也不是最新的。